Comparison of Alternative Splicing Junction Detection Tools Using RNASeq Data
نویسندگان
چکیده
منابع مشابه
Comparison of Alternative Splicing Junction Detection Tools Using RNA-Seq Data
BACKGROUND Alternative splicing (AS) is a posttranscriptional process that produces differ-ent transcripts from the same gene and is important to produce diverse protein products in response to environmental stimuli. AS occurs at specific sites on the mRNA sequence, some of which have been de-fined. Multiple bioinformatics tools have been developed to detect AS from experimental data. OBJECTI...
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Research indicates that alternative splicing (AS) is a major source contributing to the cellular and functional complexity of metazoan organisms and an important cause of disease if normal splicing is disrupted. While very recent AS sensing technologies such as microarrays and next generation sequencing can potentially be used to understand how AS operates in a tissue-specific manner, noisy dat...
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Splicing and alternative splicing are major processes in the interpretation and expression of genetic information for metazoan organisms. The study of splicing is moving from focused attention on the regulatory mechanisms of a selected set of paradigmatic alternative splicing events to questions of global integration of splicing regulation with genome and cell function. For this reason, paralle...
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Alternative splicing can alter genome sequence and as a consequence, many genes change to oncogenes. This event can also affect protein function and diversity. The growing number of study elucidate the pathological influence of impaired alternative splicing events on numerous disease including cancer. Here, we would like to highlight the significant role of alternative splicing in cancer biolog...
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3 Running ASpli 2 3.1 To BIN or not to BIN . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 3.2 Read Counting . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 3.2.1 Mapping file and bam loading . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 3.2.2 Overlap features and read ali...
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ژورنال
عنوان ژورنال: Current Genomics
سال: 2017
ISSN: 1389-2029
DOI: 10.2174/1389202918666170215125048